Leonard Shelby, an insurance investigator has developed short-term memory loss after attempting to intervene in his wife's murder, and uses notes and tattoos in an attempt to hunt down her killer.

After a man is beaten and declared dead, he suddenly sits up and walks out of the hospital on his own. Determined to start his life over in a new town and unable to remember his name or anything about his past, he becomes involved with a mother and her sons. Everything seems good until his past comes back to haunt him.

When a devastating attack leaves Mark Hogancamp shattered and without his memory, no one expected recovery. But by putting together pieces from his old and new life, Mark meticulously creates a wondrous fantasy world, where he draws strength to triumph in the real one. His astonishing art installation becomes a testament to the powerful women who support him on his journey.

A young man meets his soulmate who suffers from a memory disorder which wipes her memory clean each evening.