Siddalee Walker, a successful theater director, is thrown into a void of uncertainty when she has a falling out with her mother over a New York Times article in which Vivi is characterized as an abusive parent, and the Ya-Yas, Vivi's gang of lifelong girlfriends, conspire to restore the mother-daughter relationship.

In the small river town of La Luna, Louisiana, Calla Lily Ponder enjoys a blissful childhood at her mother's side, learns the art of healing through the humble womanly art of "fixing hair," and encounters first love with a boy named Tuck. When Tuck leaves her, Calla transforms her sorrow into inspiration and heads for the wild and colorful city of New Orleans--where she realizes the full power of her "healing hands" and Tuck presents her with an offer...

Like mother, like daughter. Neither a hard-as-nails New York playwright nor her flaky Louisiana mother will take the necessary steps to mend their long-time rift. No, this is a job for the Sisterhood, sworn life-long friends who stage an outlandish "intervention" to bring daughter and mother back together again.