John and Jane Smith are a married couple who are beginning to get bored with their quiet domestic life. What they don't know, however, is that they are both assassins, secretly traveling around the world and killing for hire. But their separate lives are about to collide when the discover they are each other's next target.

Robert Neville is the last human survivor in what is left of New York City. A pandemic has left only 1% of the population alive and most of those who survived are no longer human. The infected, now lurking in the shadows, watch Neville's every move. Perhaps mankind's last, best hope, Neville is driven by the only one remaining mission: to find a way to reverse the effects of the virus using his own immune blood.

Set in a mythic New York City and spanning more than a century, follow a story of miracles, crossed destinies, and the age-old battle between good and evil.