He's baaack! Sheldon is retrieved from his soul-searching cross-country train trip (older but no wiser) and that means the gang's all here to spread another year's cheer as TV's most attended laugh seminar. Enroll in this comic curriculum to explore Leonard's minor surgery becoming a major catastrophe from his roommate, Howard's obsession over his mom's relationship with retailer-turned-caretaker Stuart, and the peculiar results of Penny's technique...

Physicist roommates Leonard and Sheldon find their universe reorganized when a beautiful woman moves in across the hall and the two geeks realize that, while they may be brilliant when it comes to science, they are complete idiots around women.

Six friends living in Manhattan deal with relationships and problems in their lives.