In the middle of spring-cleaning, Brock's discovery of a lost videotape from Jonas Venture Sr. sets Team Venture off on a global scavenger hunt for the hidden pieces of a fantastic and potentially deadly machine. But to save humanity from a terrible fate, they'll have to overcome death, drug addiction, Jonny Quest and Professor Impossible--all under the watchful eye of the mysterious Grand Galactic Inquisitor.

The premiere episode finds Team Venture and friends struggling to pick up the pieces of their shattered lives and move on in the wake of Hank and Dean's violent and untimely deaths. While Doc searches for his soul in the far corners of the globe, Dr. Orpheus wallows in guilt, and a mullet-less Brock repairs his beloved Charger, The Monarch plots a daring prison break with the help of his fellow supervillainous inmates.

Aided by Henchmen 21, 24 and a ragtag band of roughneck new recruits, The Monarch attempts to rebuild his villainous empire and rekindle his relationship with Dr. Girlfriend. A showdown at the local shopping mall forces his hand, and as he struggles to choose between revenge and reconciliation amidst a sea of violence, a wounded Brock falls into the clutches of The Phantom Limb.

When the Guild of Calamitous Intent finally approves Dr. Orpheus for his very own arch nemesis, he calls upon old friends The Alchemist and Jefferson Twilight to resurrect their former super-team, The Order of the Triad. While they audition supervillain candidates at the Venture Compound, a jealous Doc isn't about to let Orpheus steal the show. Let loose the Walking Eye!

As Phantom Limb makes his stunning power play, only Brock can rally The Monarch's forces to mount a defense. The fate of almost everyone in the Venture universe hangs in the balance as The Sovereign reveals his true identity and guys and stuff explode all over the place.

When Dr. Venture finally succeeds in attaining the holy grail of super science--the revivification of a human corpse for fun and profit--a washed up gang of wandering former teen sleuths is convinced that the Venture Compound is haunted. Their investigation uncovers something far creepier. Meanwhile, Orpheus shepherds Brock through a crisis of conscience with the help of a New Age shaman and a bizarre tea party.

When Brock is reactivated by the Office of Secret Intelligence to track down a rogue agent, he subcontracts his ex-girlfriend, the malevolently mercenary Molotov Cocktease, to protect the Venture Compound from enemies within and without. Love is in the air! Or is it...murder?

Jack Harriman becomes an instant spiritual celebrity after humiliating Reverend Guy Roy Davis on Public-Access TV. While on the road speaking his brand of truth, forces natural and supernatural lead him to question whether he has a deeper calling.

A performing grizzly bear named Boog, who has been domesticated by a park ranger, Beth, helps deer friend Elliot escape from the mullet-sporting hunter, Shaw. When the two animals escape to the forest they become lost - just as hunting season begins. To make the situation worse, Boog doesn't know how to survive outside of his beloved ranch. Elliott and Boog develop a strong bond not only between themselves but also with the other wild animals as they...

As the result of a childhood wish, John Bennett's teddy bear, Ted, came to life and has been by John's side ever since. Their friendship is tested when Lori, John's girlfriend of four years, wants more from their relationship.