The comedic adventures of a group of doctors and interns at Sacred Heart Hospital. It's a whole new year for the staff at Sacred Heart. Elliot undergoes a complete makeover in an attempt to change her luck, and the residents discover the incredible healing powers of an epiphany toilet. Join J.D. and his fellow interns as they face more medical and comical dilemmas.

J.D. and Elliot are learning to work together after the bad breakup. Both are competing for the Chief Resident position. Turk and Carla are struggling with newlywed life. Turk is faced with some difficult health issues. J.D. and Turk's relationship sees some difficulties.

Dr. J.D. returns for his second year at Sacred Heart Hospital; filled with new relationships, medical mistakes, and the terrorizing janitor.