The result of an illegal experiment in genetic mutation, Experiment #626, is so horrifyingly hostile that it's been locked up by its inventors. It escapes to Earth where Lilo, a young Hawaiian girl, mistakes it for a strange dog, adopts it, and renames it Stitch. As Stitch becomes part of Lilo's unusual family life Lilo's innocence and the aloha spirit of the Islands confuse and ultimately civilize the creature.