Vol. Two continues the team's adventures as they traverse the outer reaches of the cosmos. The Guardians must fight to keep their newfound family together as they unravel the mystery of Peter Quill's true parentage. Old foes become new allies and fan-favorite characters from the classic comics will come to our heroes' aid as the Marvel Cinematic Universe continues to expand.

The Mane 6 must rely on friends old and new as they travel beyond Equestria to save Ponyville.