When an evil spirit known as Pitch lays down the gauntlet to take over the world, the immortal Guardians must join forces for the first time to protect the hopes, beliefs, and imagination of children all over the world.

Although he has been missing for several years and the entire town thinks her father has abandoned her family, Meg steadfastly believes the best and protects her younger brother, Charles Wallace, from the brunt of the rumors and taunting. It is he, however, who convinces her to join him, the school sports star Calvin, and three unusual women on an interplanetary voyage to rescue their father from a vast evil.