As computer hacker Lisbeth and journalist Mikael investigate a sex-trafficking ring, Lisbeth is accused of three murders, causing her to go on the run while Mikael works to clear her name.

Blamed for the terrorist bombing of the Kremlin, IMF operative Ethan Hunt is disavowed along with the rest of the agency when the President initiates 'Ghost Protocol'. Left without any resources or backup, Ethan must find a way to clear his agency's name and prevent another attack. To complicate matters further, Ethan is forced to embark on his mission with a team of fellow IMF fugitives whose personal motives he does not fully know.