Stella is worried when Sunil starts acting suspiciously. In true Stella style, she goes on an unorthodox mission to uncover the truth. Meanwhile, Luke is wrestling with news from his past.

Sister Julienne receives a phone call from Holloway Prison where the Salvation Army, who normally provide midwifery for female inmates, have been struck down with influenza. She is called to care for the women and asks Trixie to help her. Shelagh suffers heartbreak when a routine pregnancy check turns out to be something far more serious.

Jenny is concerned that a Jewish patient, Leah, is struggling to cope with her mother's sickness and agoraphobia, on top of her own pregnancy. But with the arrival of her granddaughter, Mrs. Rubin takes her first steps in years. Jenny rushes to Alec's side when he is in a terrible accident and Shelagh tries to cope with her bad news.

As Poplar is gripped by a mysterious outbreak of dysentery, first-time mother Marie Amos's life is turned upside down when her husband Tony is arrested for gross indecency with another man. Meanwhile, Nurse Crane meets Dolores McEvoy, a pregnant Irish woman with two young children who, on examination, is found to be covered in flea bites and clearly malnourished.