Set in Sydney, 1999, after an unlikely encounter at a train station, a young terminally ill girl befriends a fugitive teenage boy and they travel to visit a moon rock that the girl believes will heal her.

The honeymoon is over as the adventure in the Australian outback continues. After the birth of Nick's child with his old flame, Sally, he and Tess strain to keep their marriage together. Meanwhile, the arrival of the mysterious Regan pits McLeod versus McLeod as the girls try to save Drovers Run from their cousin's deceitful plans. Even greater shocks are in store as Jodi learns the truth about her father and Stevie reveals a secret of her own.

Tension fills the air as the truth is revealed about the father of Claire's baby. Meanwhile, the elaborate wedding planned for Jodi ends with her leaving Alberto at the altar. Emotions run deep as the biggest tragedy befalls Drovers Run.

In this season, Drovers Run is hit with more shocks and surprises than ever before. After a pregnancy scare, Tess learns that Nick, the love of her life, is still alive. Meg proposes to Terry and the girls face off against a relentless hit-man, who has been hired to kill Rob.