Stephen Pearse and Peter Maryk are doctors who once worked together to research a horrifying virus outbreak in the Congo. Now Pearse heads the Bureau of Disease Control, and Maryk runs the clandestine special pathogens section of the disease detectives- making the two scientists bitter enemies. But when the disease from the Congo re-emerges in America, they must set aside their differences in order to stop a potential worldwide epidemic....

Eph Goodweather, head of the Centers for Disease Control's team fighting a vampiric virus that has already consumed New York City, struggles to keep his infected wife from getting her hands on their young son, while a power struggle erupts between the Old and New World vampires, both of which are seeking an ancient text that contains the vampires' darkest secrets.

When a vampiric virus infecting New York begins to spread and results in a mass extermination of humans, the vampire Master chooses survivors based on compliance, while Eph and a motley group of fighters tries to find a way to stop the contagion, rescue the city, and save his son.