Elsa Mars is the proprietor of a troupe of human "curiosities" on a desperate journey of survival in the sleepy hamlet of Jupiter, Florida, in 1952. Her menagerie of performers includes a two-headed, telepathic twin, a take-charge bearded lady, a vulnerable strongman, and his three-breasted wife. But strange emergence of an entity will savagely threaten the lives of the townsfolk and freaks alike.

When Sarah, a real-life vampire, gets audited by the IRS, the last thing she expects to get out of it is a date. But James, her hopelessly romantic IRS agent, thinks she's other-worldly. As an unlikely attraction sparks between the two misfits, they are forced to confront whether they have the courage to commit the terrifying, radical act of falling in love.