An adventure story set in the world of a modern Mark Twain that begins when Zak, a young man with Down syndrome, runs away from a nursing home where he lives to chase his dream of becoming a professional wrestler and attending the wrestling school of The Salt Water Redneck, his idol. Through circumstances beyond their control, Tyler, a small-time outlaw on the run, becomes Zak's unlikely coach and ally.

Struggling with writer's block and a lackluster love life, once-famous novelist Calvin creates a beautiful fictitious character named Ruby who inspires him. But not only does this bring his work to life, it also brings Ruby to life, literally. Face-to-face with an actual relationship with his once virtual girlfriend, Calvin must now decide whether to pen this love story or let it write itself.

Kassie, a smart, fun-loving single woman, despite her neurotic best friend Wally's objections, decides it's time to have a baby, even if it means doing it herself, with a little help from a charming sperm donor. But, unbeknownst to her, Kassie's plans go awry because of a last-minute switch that isn't discovered until seven years later, when Wally gets acquainted with Kassie's cute, though slightly neurotic, son.

Olive is a little girl who dreams of winning the Little Miss Sunshine contest. Her family wants her dream to come true, but they are so dysfunctional that they can barely make it through a day without some disaster befalling them. Olive's father, Richard, is unsuccessful as a motivational speaker. He is barely on speaking terms with Olive's mother. Her uncle Frank has attempted suicide following an unsuccessful romance with a male graduate student....